Abstract
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.
MeSH terms
-
Chemotaxis, Leukocyte / drug effects*
-
Humans
-
Inhibitory Concentration 50
-
Ligands
-
Neutrophils / drug effects*
-
Nicotinic Acids / chemical synthesis*
-
Nicotinic Acids / chemistry
-
Nicotinic Acids / pharmacology*
-
Structure-Activity Relationship
Substances
-
Ligands
-
Nicotinic Acids
-
nicotinanilide